Nucleic acid-related proteins are a molecular system that uses DNA and RNA as substrates or functional platforms, broadly covering key links such as storage of genetic information, expression regulation, translation decoding, and damage repair. This system encompasses three core functional modules—chromatin epigenetic regulation, ribosomal translation synthesis, and DNA damage repair—which jointly ensure the faithful transmission and dynamic response of genomic information, forming the molecular basis for cell proliferation, differentiation, and stress adaptation; their dysfunction directly drives tumorigenesis, developmental malformations, and neurodegenerative diseases.

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