DNA Repair Proteins

DNA repair proteins are a system of enzymes and cofactors responsible for recognizing and repairing genomic DNA damage, encompassing key molecules in pathways such as base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair. By sensing DNA damage, excising abnormal bases, and resynthesizing with the correct sequence, they maintain genomic stability, serving as an important defense line against mutation accumulation and tumorigenesis.