KMD Bioscience offers one-stop in vitro aptamer selection services leveraging our well-established Systematic Evolution of Ligands by Exponential Enrichment (SELEX) platform. We perform high-throughput screening against diverse target types to identify aptamers with high affinity and exceptional specificity, enabling our clients to accelerate research programs while reducing development costs.
Aptamers are single-stranded DNA or RNA oligonucleotides typically 20–80 nucleotides in length. Through intramolecular folding, they adopt precise three-dimensional conformations such as hairpins, G-quadruplexes, and pseudoknots, enabling specific recognition of target molecules with dissociation constants (Kd) ranging from nanomolar to picomolar levels—hence they are often referred to as "chemical antibodies." RNA aptamers, owing to the presence of the 2'-hydroxyl group on ribose, exhibit greater conformational diversity and binding flexibility, whereas DNA aptamers offer superior chemical stability and ease of synthesis and modification. The choice between RNA and DNA formats can be tailored to the target characteristics and downstream application requirements.
Aptamers have found broad applications in basic life science research, clinical in vitro diagnostics, targeted drug development, and biosensing. KMD Bioscience provides a comprehensive end-to-end service covering random library design, iterative binding selection and enrichment, high-throughput sequencing analysis, and affinity/specificity validation. In addition to classical targets such as proteins and small molecules, we also support customized strategies including cell-based differential selection (Cell-SELEX), which enables precise identification of molecular signatures distinguishing different cellular phenotypes, thereby accommodating diverse research needs.
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