Mice are small mammals belonging to the order Rodentia and the family Muridae. They are one of the most commonly used model organisms in laboratories. The mouse genome shares a high degree of homology with the human genome, with about 99% of human genes having corresponding homologs in mice. Therefore, studying mouse gene functions can be directly applied to human biology. Using gene editing technology, human diseases can be simulated in mice to create disease models for observing disease progression and drug efficacy.
The core application of gene knock-in technology lies in constructing human disease models. Single base mutations or gene misplacement discovered in human genomics research are the root causes of many diseases, especially genetic disorders. By introducing point mutations or exogenous fragments into target sites via gene knock-in, disease models can be established in cultured cell lines or model organisms.
KMD Bioscience, with its extensive experience in genetic engineering, has established a gene editing platform based on the CRISPR/Cas9 system. The company provides animal gene knock-in vector construction services, including for model animals such as mice, zebrafish, and rabbits.
Animals | Disease Models |
Mouse | Tumors (lung cancer, pancreatic cancer, prostate cancer, gastric cancer, liver cancer, colon cancer, etc.); Metabolic (pulmonary fibrosis, diabetes models, obesity models); Depression models; |
Rabbit | Diabetes models, progeria models, rickets models, intracerebral hemorrhage models, spinal cord glioma models, brain glioma models, migraine models, Parkinson’s disease models, Alzheimer’s disease models; |
Pig | Diabetes models, progeria models, rickets models, intracerebral hemorrhage models, spinal cord glioma models, brain glioma models; |
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