Chromatin Epigenetics

Chromatin epigenetics-related proteins are a molecular system that regulates chromatin accessibility through chemical modification or structural remodeling, encompassing histone-modifying enzymes, DNA methyltransferases, chromatin remodeling complexes, and various reader proteins that recognize modified signals. Through covalent modifications such as acetylation, methylation, and phosphorylation, they dynamically regulate gene transcription activity, achieving spatiotemporal control of gene expression without altering the DNA sequence, representing an important regulatory mechanism for cell differentiation, development, and environmental responses.