Blood/heme proteins are a protein system present in the circulatory system or involved in oxygen transport and heme metabolism, encompassing hemoglobin, plasma proteins, coagulation factors, and heme-binding proteins. They perform core functions in oxygen delivery, acid-base balance maintenance, coagulation and fibrinolysis regulation, and heme homeostasis; their aberrant expression is closely associated with various blood system diseases such as anemia, coagulation disorders, and porphyria.

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