Hepatitis viruses

Hepatitis viruses cause viral hepatitis and include HBV, HCV, HAV, HDV, and HEV. HBV surface antigen HBsAg is the core vaccine and diagnostic marker; core HBcAg and e antigen HBeAg hold serologic value, and polymerase Pol is an antiviral target. HCV Core and nonstructural NS3/4A, NS5A, NS5B (polymerase) are core to diagnostics and direct-acting antivirals (DAAs); HAV capsid VP1–VP3 and HEV ORF2 capsid aid vaccines and diagnostics. Recombinant HBsAg, HBcAg, HCV Core/NS3/NS5A/NS5B, HAV VP, and HEV ORF2 support hepatitis diagnostics, vaccine development, and antiviral R&D.