HCV (HCV-1a) NS3 Protease Protein, GST Tag
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Product Number
KMP4814
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Alias
HCV NS3 Protease, Helicase Immunodominant Region Protein, HCV NS3 Protease Protein
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Specifications
- 50 µg
- 100 µg
- 200 µg
Product Description
| Alias | HCV NS3 Protease, Helicase Immunodominant Region Protein, HCV NS3 Protease Protein |
| Catalog Number | KMP4814 |
| Product Description | The HCV (HCV-1a) NS3 Protease Protein(KMP4814) is produced in E. coli. A DNA sequence encoding the Hepatitis C virus (HCV)(serotype 1a, isolate H77) NS3 (NP_803144.1) (Thr1356-Thr1459) was expressed with a GST tag at the N-terminus. |
| Molecular Name | HCV NS3 Protease |
| Species | HCV |
| Host | E. coli |
| Size | 50 µg, 100 µg, 200 µg |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity. |
| Storage Condition | Aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
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