Receptor Tyrosine Kinases

Receptor tyrosine kinases are single-pass transmembrane receptors with intrinsic tyrosine kinase activity; ligand binding induces receptor dimerization, activates the intracellular kinase domain, and initiates downstream signaling cascades such as Ras/MAPK and PI3K/AKT, thereby regulating cell proliferation, differentiation, and metabolism. These receptors are the core switch for cell fate regulation, and their mutation or overexpression is closely associated with the occurrence and development of various malignant tumors, making them one of the most prominent target classes in targeted drug development.