Nuclear Receptors

Nuclear receptors are intracellular ligand-dependent transcription regulators that, upon ligand binding, enter the nucleus to directly bind DNA and regulate target gene expression. They play key roles in immune regulation, metabolic homeostasis, developmental differentiation, and inflammation control. Because their ligands can cross the cell membrane and be modulated by small-molecule compounds, nuclear receptors have become successful drug intervention targets in anti-inflammatory, lipid-lowering, and metabolic disease therapies.