Molecular Chaperones

Molecular chaperones are auxiliary proteins that assist the correct folding, assembly, and transport of newly synthesized proteins, while also participating in the recognition and degradation of misfolded proteins, playing a central role in maintaining protein homeostasis. They primarily mediate ATP-dependent conformational changes to regulate protein quality control, protecting cells from protein aggregation damage under stress conditions, and are closely associated with various neurodegenerative diseases and aging.