Cytochrome P450

Cytochrome P450 is a superfamily of heme-dependent oxidases that play a key role in drug metabolism, hormone synthesis, and detoxification of exogenous substances. Through monooxygenase reactions, they catalyze phase I metabolic reactions such as hydroxylation and epoxidation of substrates, serving as the core participant in hepatic drug metabolism; their polymorphisms are an important cause of inter-individual differences in drug response.