Apolipoproteins are functional proteins that bind and transport lipid molecules, mainly present on the surface of plasma lipoprotein particles. They not only serve as structural carriers for lipid transport but also mediate the uptake and clearance of lipoproteins by recognizing cell-surface receptors, while acting as cofactors that regulate the activity of key enzymes in lipid metabolism, playing a core role in reverse cholesterol transport and triglyceride metabolism, and are closely associated with cardiovascular diseases such as atherosclerosis.

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