Murine antibody

Murine antibodies are produced by mouse hybridoma or mouse immunization, with fully mouse sequences, the earliest antibody format used in research and therapy. Mature, low-cost, and easy to affinity-screen, they remain workhorses for WB, IHC, IF, ELISA, and FACS research reagents; however, fully xenogeneic sequences trigger human anti-mouse antibody (HAMA) responses in humans, limiting therapeutic use—mostly serving as parental/positive controls for humanization. Recombinant murine mAbs/polyclonals and mouse IgG/light-chain proteins support research reagents, humanization starting points, and immunogenicity controls.