Caninized antibody

Caninized antibodies are canine or canine-engineered antibodies for veterinary and comparative medicine, generated by grafting the variable regions of anti-canine antigen murine antibodies onto a canine framework (caninization) or screening canine immune libraries, reducing anti-antibody responses in dogs for diagnosing and treating canine tumors, inflammation, and chronic disease. Caninized antibodies are increasingly valuable in pet precision medicine, veterinary drug R&D, and canine disease models. Recombinant caninized antibodies and canine IgG/Fc/variable-region proteins support veterinary diagnostics, pet mAb drug development, and canine immunogenicity assessment.