Mouse Anti Human respiratory syncytial virus (RSV) Glycoprotein G Antibody
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Product Number
SMAG3244
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Alias
Anti-G Antibody
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Specifications
- 50ul
- 100ul
Product Description
| Alias | Anti-G Antibody |
| Catalog Number | SMAG3244 |
| Product Description | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RSV Glycoprotein G. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Host | Mouse |
| Size | 50ul,100ul |
| Clonity | Monoclonal |
| Purification | 亲和纯化 |
| Formulation | 0.2 μm filtered solution in PBS. |
| Background | Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. HRSV G protein is a type II glycoprotein of 289-299 amino acids (depending on the virus strain) with a signal/anchor hydrophobic domain and is extensively modified by the addition of both N-and O-linked oligosaccharides to achieve the mature form of 8-9 kDa. The C-terminal ectodomain of the G protein has a central region and four cysteines which are conserved in all HRSV isolates and have been proposed as the putative receptor binding site. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. As similar to mucins in amino acid compositions, the RSV G protein can interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, and thus modulates the immune response and facilitate infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and hemagglutinating activities. |
| Immunogen | Recombinant Human RSV Glycoprotein G / RSV-G |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-1:1000 ELISA 1:1000-1:2000 |
| Tag | Unconjugated |
| Storage Condition | Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | 冰袋运输 |
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