Developmental Signaling Ligands

Developmental signaling ligands are signaling molecules that exert directed regulatory roles in embryonic development and tissue morphogenesis, precisely guiding cell fate determination, polarity establishment, and pattern formation through highly conserved signaling pathways. These ligands not only determine the spatiotemporal order of embryonic development but also play important roles in adult tissue homeostasis maintenance and post-injury regeneration; their signaling aberrations can lead to developmental defects and various genetic diseases.