SARS S2 Protein
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Product Number
KMP4903
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Alias
冠状病毒刺突蛋白S2, SARS S2, Spike2 Protein, SARS S2 Protein
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 冠状病毒刺突蛋白S2, SARS S2, Spike2 Protein, SARS S2 Protein |
| Catalog Number | KMP4903 |
| Product Description | The SARS S2 Protein(KMP4903) is produced in Insect Cells. A DNA sequence encoding the SARS-CoV spike S2 (NP_828851.1) (Ser668-Pro1195) was expressed with a C-terminal polyhistidine tag. |
| Molecular Name | SARS S2 |
| Species | SARS |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 50mM Tris, 500mM NaCl |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
FAQ
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Q1-S2亚基的功能是什么？
S2包含融合肽（FP）、七肽重复区1/2（HR1/HR2），介导病毒与宿主细胞膜融合，是泛冠状病毒抑制剂（如EK1多肽）的靶点。
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Q2-该蛋白是否保留膜融合活性？
需在酸性pH条件下激活，通过脂质体融合实验或细胞-细胞融合模型验证其功能。
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Q3-能否用于结构生物学研究？
是的，HR1-HR2复合物可形成六螺旋束（6-HB），是X射线晶体学或冷冻电镜的热门靶点。
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Q4-未添加标签如何纯化？
通过离子交换层析（如SP柱）或疏水相互作用层析（HIC）纯化，依赖蛋白表面电荷和疏水性。
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Q5-是否支持广谱抗冠状病毒药物筛选？
是的，S2区域在冠状病毒中高度保守，可筛选靶向融合过程的抑制剂。
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