What are the targets of FLT3 ligand?

It acts on hematopoietic stem/progenitor cells expressing the Flt3 receptor (CD135), which is crucial for their proliferation and survival.

Why is it the core of hematopoietic expansion protocols?

Because it specifically supports the most primitive hematopoietic stem/progenitor cells, and the combination of SCF and TPO is the golden combination for the in vitro efficient expansion of hematopoietic stem cells and progenitor cells.

Recombinant Human FLT3LG Protein, His Tag

Product Number

KRP699

Alias

P36888, Flt-3 Ligand, CD135, FLK-2, FLK2, STK1

Specifications

100ug
500ug
1mg

DATASHEET MSDS

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Product Description

Alias	P36888, Flt-3 Ligand, CD135, FLK-2, FLK2, STK1
Catalog Number	KRP699
Product Introduction	Recombinant human Flt-3 ligand is a key growth factor for the development of dendritic cells and hematopoietic stem cells. Mainly used for in vitro generation of dendritic cells, immunotherapy research, and hematopoietic expansion experiments.
Molecular Name	FLT3LG
Species	Human
Host	Sf9 Cells
Size	100ug,500ug,1mg
Purity	>95%, determined by SDS-PAGE.
Concentration	Contact the sales manager to obtain the concentration of the latest batch.
Purification	Affinity Purification
Endotoxin	<0.1 EU/μg, determined by LAL method.
Background	A ligand for Flt-3 receptor (CD135), important for proliferation and differentiation of hematopoietic stem cells and dendritic cell precursors, studied as a mobilizer of dendritic cells in immunotherapy.
Application	WB, ELISA
Predicted Molecular Weight	17.5 kDa
Reconstitution	It is recommended that the lyophilized human Flt-3 Ligand protein be dissolved in PBS at a concentration of 100-200 μg/ml for further dilution as the working concentration.
Storage Condition	Samples are stable for up to twelve months from date of receipt at -20℃ to -103℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Stability	Repeated freezing and thawing is not recommended.
Molecular Weight	1730 kDa,
Uniprot ID	P49771
References	1. WodnarFilipowicz, A. (2003) News Physiol. Sci. 18:247. 2. Dong, J. et al. (2002) Cancer Biol. Ther. 1:486. 3. Gilliland, D.G. and J.D. Griffin (2002) Blood 100:1532. 4. Hannum, C. et al. (1994) Nature 368:643. 5. Lyman, S.D. et al. (1994) Blood 83:2795. 6. Lyman, S.D. et al. (1993) Cell 75:1157. 7. Savvides, S.N. et al. (2000) Nat. Struct. Biol. 7:486. 8. McClanahan, T. et al. (1996) Blood 88:3371. 9. Diener, K.R. et al. (2008) Exp. Hematol. 36:51. 10. Farag, S.S. and M.A. Caligiuri (2006) Blood Rev. 20:123. 11. Edwan, J.H. et al. (2004) J. Immunol. 172:5016.1. WodnarFilipowicz, A. (2003) News Physiol. Sci. 18:247. 2. Dong, J. et al. (2002) Cancer Biol. Ther. 1:486. 3. Gilliland, D.G. and J.D. Griffin (2002) Blood 100:1532. 4. Hannum, C. et al. (1994) Nature 368:643. 5. Lyman, S.D. et al. (1994) Blood 83:2795. 6. Lyman, S.D. et al. (1993) Cell 75:1157. 7. Savvides, S.N. et al. (2000) Nat. Struct. Biol. 7:486. 8. McClanahan, T. et al. (1996) Blood 88:3371. 9. Diener, K.R. et al. (2008) Exp. Hematol. 36:51. 10. Farag, S.S. and M.A. Caligiuri (2006) Blood Rev. 20:123. 11. Edwan, J.H. et al. (2004) J. Immunol. 172:5016.
Function	Recombinant Human Flt-3 Ligand is a key growth factor for the development of dendritic cells and hematopoietic stem cells. It is primarily used for the in vitro generation of dendritic cells, research on immunotherapy, and hematopoietic expansion experiments.
Product Declaration	This product is for research use only and must not be used directly on the human body or for injection.
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -43℃. Avoid repeated freeze-thaw cycles.
Product Full Name	Recombinant Human Flt-3 Ligand Protein
Target	Flt-3

FAQ

What are the targets of FLT3 ligand?

It acts on hematopoietic stem/progenitor cells expressing the Flt3 receptor (CD135), which is crucial for their proliferation and survival.
Why is it the core of hematopoietic expansion protocols?

Because it specifically supports the most primitive hematopoietic stem/progenitor cells, and the combination of SCF and TPO is the golden combination for the in vitro efficient expansion of hematopoietic stem cells and progenitor cells.

PRODUCT CENTER

Recombinant Human FLT3LG Protein, His Tag

Product Number

Alias

Specifications

What are the targets of FLT3 ligand?

Why is it the core of hematopoietic expansion protocols?

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