Recombinant Human TGF-β1 Protein
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Product Number
KRP696
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Alias
TGFB, TGFB1, Transforming growth factor beta-1 proprotein
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Specifications
- 100ug
- 500ug
- 1mg
Product Description
| Alias | TGFB, TGFB1, Transforming growth factor beta-1 proprotein |
| Catalog Number | KRP696 |
| Product Introduction | Recombinant human transforming growth factor - β 1 is a multifunctional cytokine that regulates cell growth, differentiation, and immune suppression. Widely used in fibrosis research, immune regulation experiments, stem cell differentiation, and cancer metastasis models. |
| Molecular Name | TGF-β1 |
| Species | Human |
| Host | Sf9 Cells |
| Size | 100ug,500ug,1mg |
| Purity | >95%, determined by SDS-PAGE. |
| Concentration | Contact the sales manager to obtain the concentration of the latest batch. |
| Purification | Affinity Purification |
| Endotoxin | <0.1 EU/μg, determined by LAL method. |
| Background | A multifunctional cytokine of the transforming growth factor beta family, playing a central role in cell proliferation, differentiation, apoptosis, immune regulation , and extracellular matrix generation, and is a key regulator of fibrosis, cancer, and immune diseases. |
| Application | WB, ELISA |
| Predicted Molecular Weight | 12.8 kDa |
| Reconstitution | It is recommended that the lyophilized human TGF-β1 protein be dissolved in 4 mM HCl at a concentration of 100 μg/ml for further dilution as the working concentration. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -100℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Stability | Repeated freezing and thawing is not recommended. |
| Molecular Weight | 10-11 kDa |
| Uniprot ID | P01137 |
| References | 1. Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29. 2. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982. 3. Wahl, S.M. (2006) Immunol. Rev. 213:213. 4. Chang, H. et al.(2002) Endocr. Rev. 23:787. 5. Lin, J.S. et al. (2006) Reproduction 132:179. 6. Hinck, A.P. et al.(1996) Biochemistry 35:8517. 7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261. 8. Derynck, R. et al. (1985) Nature 316:701. 9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407. 10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601. 11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1. 12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052. |
| Function | Recombinant human transforming growth factor-β1 is a multifunctional cytokine that regulates cell growth, differentiation, and immune suppression. It is widely used in fibrosis research, immune modulation experiments, stem cell differentiation, and cancer metastasis models. |
| Product Declaration | This product is for research use only and must not be used directly on the human body or for injection. |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -40℃. Avoid repeated freeze-thaw cycles. |
| Product Full Name | Recombinant Human TGF-β1 Protein |
| Target | TGF-β1 |
FAQ
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What are the functional characteristics of TGF-β?
It has multiple, environment-dependent functions, including inhibition of cell proliferation, regulation of immunity, and strong induction of extracellular matrix production and mesenchymal differentiation.
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What is its most classic application in stem cell culture?
Low concentrations of TGF-β1/β3 are the gold standard core factors for inducing mesenchymal stem cells to differentiate into chondrocytes. In addition, it is also used to induce pluripotent stem cells to differentiate into mesenchymal stem cells or regulatory T cells.
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