Recombinant Human IL15 Protein, His Tag
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Product Number
KRP694
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Alias
Interleukin-15, IL-15, IL15
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Specifications
- 100ug
- 500ug
- 1mg
Product Description
| Alias | Interleukin-15, IL-15, IL15 |
| Catalog Number | KRP694 |
| Product Introduction | Recombinant human interleukin-15 is a key cytokine that promotes the survival and function of NK cells and memory T cells. Commonly used for NK cell expansion, immune memory research, and cancer immunotherapy experiments. |
| Molecular Name | IL15 |
| Species | Human |
| Host | E.coli |
| Size | 100ug,500ug,1mg |
| Purity | >97%, determined by SDS-PAGE. |
| Concentration | Contact the sales manager to obtain the concentration of the latest batch. |
| Purification | Affinity Purification |
| Endotoxin | <0.01 EU/μg, determined by LAL method. |
| Background | Structurally similar to IL-2, but functionally different, mainly produced by monocytes/macrophages and epithelial cells, is a key factor for the development, survival, and function maintenance of natural killer (NK) cells and memory CD8+ T cells. |
| Application | WB, ELISA |
| Predicted Molecular Weight | 12.5 kDa |
| Reconstitution | It is recommended that the lyophilized human IL-15 protein be dissolved in PBS at a concentration of 100 μg/ml for further dilution as the working concentration. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -98℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Stability | Repeated freezing and thawing is not recommended. |
| Uniprot ID | P40933 |
| References | 1. De Sabatino, A. et al. (2011) Cytokine Growth Factor Rev. 22:19. 2. Grabstein, K. et al. (1994) Science 264:965. 3. Tagaya, Y. et al. (1997) Proc. Natl. Acad. Sci. USA 94:14444. 4. Giri, J.G. et al. (1995) EMBO J. 14:3654. 5. Giri, J. et al. (1994) EMBO J. 13:2822. 6. Dubois, S. et al. (2002) Immunity 17:537. 7. Castillo, E.F. and K.S. Schluns (2012) Cytokine 59:479. 8. Budagian, V. et al. (2004) J. Biol. Chem. 279:40368. 9. Mortier, E. et al. (2004) J. Immunol. 173:1681. 10. Bergamaschi, C. et al. (2012) Blood 120:e1. 11. Budagian, V. et al. (2004) J. Biol. Chem. 279:42192. 12. Mortier, E. et al. (2003) J. Exp. Med. 205:1213. 13. Gordy, L.E. et al. (2011) J. Immunol. 187:6335. 14. Harris, K.M. (2011) J. Leukoc. Biol. 90:727. 15. Xia, J. et al. (2010) Clin. Immunol. 134:130. 16. Schluns, K.S. et al. (2002) J. Immunol. 168:4827. 17. Davies, E. et al. (2010) J. Leukoc. Biol. 88:529. 18. Barra, N.G. et al. (2010) Obesity 18:1601. |
| Function | Recombinant Human Interleukin-15 is a key cytokine for the survival and function of NK cells and memory T cells. It is commonly used for the expansion of NK cells, research on immune memory, and experiments in cancer immunotherapy. |
| Product Declaration | This product is for research use only and must not be used directly on the human body or for injection. |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -38℃. Avoid repeated freeze-thaw cycles. |
| Product Full Name | Recombinant Human IL-15 Protein |
| Target | IL-15 |
FAQ
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Which type of immune cells does IL-15 mainly support?
It mainly supports the development, proliferation, activation, and survival of natural killer cells and memory CD8+ T cells.
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What is its role in the production of immune cell therapy products?
It is a key inducing factor for the directional and efficient differentiation of NK cells from hematopoietic stem cells or iPSCs; it is also the core growth factor for in vitro expansion and maintenance of NK cell therapy products.
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