What are the functions of GM-CSF?

Granulocyte-macrophage colony-stimulating factor stimulates the differentiation of myeloid progenitor cells into granulocytes and macrophages/dendritic cells.

What are its main uses in stem cell differentiation?

In combination with IL-4, it is the standard protocol for generating dendritic cells from hematopoietic progenitor cells or monocytes in vitro; it is also used to regulate the differentiation and polarization of macrophages.

Recombinant Human GM-CSF/CSF2 Protein, No Tag

Product Number

KRP692

Alias

GMCSF, CSF2, Granulocyte-macrophage colony-stimulating factor, GM-CSF

Specifications

100ug
500ug
1mg

DATASHEET MSDS

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Product Description

Alias	GMCSF, CSF2, Granulocyte-macrophage colony-stimulating factor, GM-CSF
Catalog Number	KRP692
Product Introduction	Recombinant human granulocyte macrophage colony-stimulating factor is a key regulatory factor for the differentiation and activation of myeloid cells. Mainly used for in vitro differentiation of granulocytes and macrophages, research on immune adjuvants, and development of tumor vaccines.
Molecular Name	CSF2
Species	Human
Host	E.coli
Size	100ug,500ug,1mg
Purity	>97%, determined by SDS-PAGE.
Concentration	Contact the sales manager to obtain the concentration of the latest batch.
Purification	Affinity Purification
Endotoxin	<0.01 EU/μg, determined by LAL method.
Background	A colony-stimulating factor that stimulates the generation and function of granulocytes and macrophages, playing a role in inflammation and immune responses, also used to accelerate neutrophil recovery after chemotherapy.
Application	WB, ELISA
Predicted Molecular Weight	14.5 kDa
Reconstitution	It is recommended that the lyophilized human GM-CSF protein be dissolved in PBS at a concentration of 100-200 μg/ml for further dilution as the working concentration.
Storage Condition	Samples are stable for up to twelve months from date of receipt at -20℃ to -96℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Stability	Repeated freezing and thawing is not recommended.
Molecular Weight	14 kDa
Uniprot ID	P04141
References	1. MartinezMoczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653. 2. Barreda, D.R. et al. (2004) Dev. Comp. Immunol. 28:509. 3. Eksioglu, E.A. et al. (2007) Exp. Hematol. 35:1163. 4. Cao, Y. (2007) J. Clin. Invest. 117:2362. 5. Fleetwood, A.J. et al. (2005) Crit. Rev. Immunol. 25:405. 6. Heuser, M. et al. (2007) Semin. Hematol. 44:148. 7. Hege, K.M. et al. (2006) Int. Rev. Immunol. 25:321. 8. Kaushansky, K. et al. (1992) Biochemistry 31:1881. 9. Diederichs, K. et al. (1991) Science 254:1779. 10. Cantrell, M.A. et al. (1985) Proc. Natl. Acad. Sci. 82:6250. 11. Lee, F. et al. (1985) Proc. Natl. Acad. Sci. 82:4360. 12. Wong, G.G. et al. (1985) Science 228:810. 13. OnettoPothier, N. et al. (1990) Blood 75:59. 14. Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. 87:9655. 15. Pelley, J.L. et al. (2007) Exp. Hematol. 35:1483. 16. Hogge, G.S. et al. (1990) Cancer Gene Ther. 6:26. 17. Sprague, W.S. et al. (2005) J. Comp. Pathol. 133:136. 18. Shanafelt, A.B. et al. (1991) J. Biol. Chem. 266:13804.
Function	Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is a key regulatory factor for the differentiation and activation of myeloid cells. It is mainly used for the in vitro differentiation of granulocytes and macrophages, research on immune adjuvants, and development of tumor vaccines.
Product Declaration	This product is for research use only and must not be used directly on the human body or for injection.
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -36℃. Avoid repeated freeze-thaw cycles.
Product Full Name	Recombinant Human GM-CSF Protein
Target	GM-CSF

FAQ

What are the functions of GM-CSF?

Granulocyte-macrophage colony-stimulating factor stimulates the differentiation of myeloid progenitor cells into granulocytes and macrophages/dendritic cells.
What are its main uses in stem cell differentiation?

In combination with IL-4, it is the standard protocol for generating dendritic cells from hematopoietic progenitor cells or monocytes in vitro; it is also used to regulate the differentiation and polarization of macrophages.

PRODUCT CENTER

Recombinant Human GM-CSF/CSF2 Protein, No Tag

Product Number

Alias

Specifications

What are the functions of GM-CSF?

What are its main uses in stem cell differentiation?

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