Recombinant Human KITLG/SCF Protein, His Tag
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Product Number
KRP690
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Alias
MGF, SCF, KITLG, Kit ligand
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Specifications
- 100ug
- 500ug
- 1mg
Product Description
| Alias | MGF, SCF, KITLG, Kit ligand |
| Catalog Number | KRP690 |
| Product Introduction | Recombinant human stem cell factor is a key factor for the survival and proliferation of hematopoietic stem cells and mast cells. Commonly used for in vitro maintenance of hematopoietic stem cells, research on mast cell differentiation, and tissue regeneration experiments. |
| Molecular Name | KITLG |
| Species | Human |
| Host | E.coli |
| Size | 100ug,500ug,1mg |
| Purity | >97%, determined by SDS-PAGE. |
| Concentration | Contact the sales manager to obtain the concentration of the latest batch. |
| Purification | Affinity Purification |
| Endotoxin | <0.01 EU/μg, determined by LAL method. |
| Background | Also known as KIT ligand, is the ligand for the c-KIT receptor, crucial for the survival, proliferation, and migration of various stem/progenitor cells such as hematopoietic stem cells, germ cells, and melanocytes. |
| Application | WB, ELISA |
| Predicted Molecular Weight | 19 kDa |
| Reconstitution | It is recommended that the lyophilized human SCF protein be dissolved in PBS at a concentration of 100 μg/mL for further dilution as the working concentration. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -95℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Stability | Repeated freezing and thawing is not recommended. |
| Uniprot ID | P21583 |
| References | 1. Ashman, L.K. (1999) Int. J. Biochem. Cell Biol. 31:1037. 2. Sette, C. et al. (2000) Int. J. Dev. Biol. 44:599. 3. Yoshida, H. et al. (2001) J. Invest. Dermatol. Symp. Proc. 6:1. 4. Erlandsson, A. et al. (2004) Exp. Cell Res. 301:201. 5. Kapur, R. et al. (2002) Blood 100:1287. 6. Wang, C.H. et al. (2007) Arterioscler. Thromb. Vasc. Biol. 27:540. 7. Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 8. Reber, L. et al. (2006) Eur. J. Pharmacol. 533:327. 9. Martin, F.H. et al. (1990) Cell 63:203. 10. Arakawa, T. et al. (1991) J. Biol. Chem. 266:18942. 11. Majumdar, M.K. et al. (1994) J. Biol. Chem. 269:1237. 12. Brannan, C.I. et al. (1991) Proc. Natl. Acad. Sci. 88:4671. 13. Anderson, D.M. et al. (1991) Cell Growth Differ. 2:373. 14. Lemmon, M.A. et al. (1997) J. Biol. Chem. 272:6311. 15. Kanellakis, P. et al. (2006) Cardiovasc. Res. 70:117 |
| Function | Recombinant Human Stem Cell Factor is a key factor for the survival and proliferation of hematopoietic stem cells and mast cells. It is commonly used in the maintenance of hematopoietic stem cells in vitro, differentiation research of mast cells, and tissue regeneration experiments. |
| Product Declaration | This product is for research use only and must not be used directly on the human body or for injection. |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -35℃. Avoid repeated freeze-thaw cycles. |
| Product Full Name | Recombinant Human SCF Protein |
| Target | SCF |
FAQ
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What is SCF? What is its receptor?
It is the stem cell factor, the ligand for c-Kit receptor (CD117), which is crucial for the survival and self-renewal of various stem/progenitor cells.
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Why is it indispensable in hematopoietic stem cell culture?
It is the cornerstone factor for maintaining and expanding hematopoietic stem cells, almost all in vitro HSC expansion protocols include SCF, and it has a strong synergistic effect with other factors (such as TPO, FLT3-L).
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