Recombinant Human TNF-alpha Protein, His Tag

Product Number

KRP685

Alias

TNFA, TNFSF2, TNF, Tumor necrosis factor

Specifications

100ug
500ug
1mg

DATASHEET MSDS

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Product Description

Alias	TNFA, TNFSF2, TNF, Tumor necrosis factor
Catalog Number	KRP685
Product Introduction	Recombinant human tumor necrosis factor alpha is a core cytokine that mediates inflammatory response and cell apoptosis. Widely used in inflammation signaling pathway research, tumor cell toxicity experiments, and autoimmune disease models.
Molecular Name	TNF
Species	Human
Host	E.coli
Size	100ug,500ug,1mg
Purity	>97%, determined by SDS-PAGE.
Concentration	Contact the sales manager to obtain the concentration of the latest batch.
Purification	Affinity Purification
Endotoxin	<0.01 EU/μg, determined by LAL method.
Background	A key pro-inflammatory cytokine mainly produced by macrophages and T cells, playing a central role in systemic inflammation, immune regulation, and cell survival/death, and is an important therapeutic target for autoimmune diseases such as rheumatoid arthritis and psoriasis.
Application	WB, ELISA
Predicted Molecular Weight	17 kDa
Reconstitution	It is recommended that the lyophilized human TNF-a protein be dissolved in sterile deionized water at a concentration of 0.1-1 mg/mL for further dilution as the working concentration.
Storage Condition	Samples are stable for up to twelve months from date of receipt at -20℃ to -89℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Stability	Repeated freezing and thawing is not recommended.
Molecular Weight	17 kDa
Uniprot ID	P01375
References	1. Zelova, H. and J. Hosek (2013) Inflamm. Res. 62:641. 2. Juhasz, K. et al. (2013) Expert Rev. Clin. Immunol. 9:335. 3. Pennica, D. et al. (1984) Nature 312:724. 4. Tang, P. et al. (1996) Biochemistry 35:8216. 5. Perez, C. et al. (1990) Cell 63:251. 6. Black, R.A. et al. (1997) Nature 385:729. 7. Moss, M.L. et al. (1997) Nature 385:733. 8. Gearing, A.J.H. et al. (1994) Nature 370:555. 9. Schall, T.J. et al. (1990) Cell 61:361. 10. Loetscher, H. et al. (1990) Cell 61:351. 11. Dembic, Z. et al. (1990) Cytokine 2:231. 12. Smith, C.A. et al. (1990) Science 248:1019. 13. Loetscher, H. et al. (1991) J. Biol. Chem. 266:18324. 14. Pinckard, J.K. et al. (1997) J. Biol. Chem. 272:10784. 15. Engelmann, H. et al. (1990) J. Biol. Chem. 265:1531.
Function	Recombinant Human Tumor Necrosis Factor-α is a core cytokine that mediates inflammatory responses and cellular apoptosis. It is widely used in research on inflammatory signaling pathways, cytotoxicity experiments on tumor cells, and models of autoimmune diseases.
Product Declaration	This product is for research use only and must not be used directly on the human body or for injection.
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -29℃. Avoid repeated freeze-thaw cycles.
Product Full Name	Recombinant Human TNF-a Protein
Target	TNF-a

FAQ

What is the nature of TNF-α?

It is a key pro-inflammatory cytokine that plays a central role in acute inflammation, immune regulation, and induction of cell apoptosis.
How is it used to regulate stem cells?

It is typically not used as a growth factor, but rather as a conditional signal. It is often used for 'inflammatory preconditioning' of mesenchymal stem cells to enhance their immunosuppressive function and chemotactic ability; it is also used to mimic the inflammatory microenvironment of diseases.

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Recombinant Human TNF-alpha Protein, His Tag

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