Recombinant Human LR3 IGF-I Protein

Product Number

KRP683

Alias

Long R3 IGF-I, LR3 Insulin-like growth factor I, Insulin-like growth factor 1, IGF-I LR3, IGFI,

Specifications

100ug
500ug
1mg

DATASHEET MSDS

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Product Description

Alias	Long R3 IGF-I, LR3 Insulin-like growth factor I, Insulin-like growth factor 1, IGF-I LR3, IGFI,
Catalog Number	KRP683
Product Introduction	Recombinant human long-acting IGF-1 variant (LR3 IGF-1) has enhanced stability and biological activity. Suitable for long-term cell proliferation research, muscle regeneration experiments, and exploration of metabolic disease-related mechanisms.
Molecular Name	IGF1
Species	Human
Host	E.coli
Size	100ug,500ug,1mg
Purity	>97%, determined by SDS-PAGE.
Concentration	Contact the sales manager to obtain the concentration of the latest batch.
Purification	Affinity Purification
Endotoxin	<0.01 EU/μg, determined by LAL method.
Background	A long-acting analogue of IGF-1, which through amino acid substitutions and N-terminal extension peptide reduces its affinity for binding proteins , thereby enhancing its bioactivity and stability, mainly used for scientific research.
Application	WB, ELISA
Predicted Molecular Weight	9 kDa
Reconstitution	It is recommended that the lyophilized human LR3 IGF-I protein be dissolved in 100 mM Acetic Acid at a concentration of 100-200 μg/mL for further dilution as the working concentration.
Storage Condition	Samples are stable for up to twelve months from date of receipt at -20℃ to -87℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Stability	Repeated freezing and thawing is not recommended.
Molecular Weight	8 kDa,
Uniprot ID	P05019
References	1. Philippou, A. et al. (2007) In Vivo 21:45. 2. Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275. 3. Berryman, D.E. et al. (2013) Nat. Rev. Endocrinol. 9:346. 4. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890. 5. Sadagurski, M. and M.F. White (2013) Endocrinol. Metab. Clin. North Am. 42:127. 6. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620. 7. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577. 8. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275. 9. Malemud, C.J. (2007) Clin. Chim. Acta 375:10. 10. Ling, P.R. et al. (1995) Am. J. Clin. Nutr. 61:116. 11. Sheng, M.H. et al. (2014) J. Bone Metab. 21:41. 12. Samani, A.A. et al. (2007) Endocrine Rev. 28:20. 13. Gallagher, E.J. et al. (2010) Endocr. Pract. 16:864. 14. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302. 15. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421. 16. Duan, C. and Q. Xu (2005) Gen. Comp. Endocrinol. 142:44. 17. Francis, G.L. et al. (1992) J. Mol. Endocrinol. 8:213. 18. Voorhamme, D. and C.A. Yandell (2006) Mol. Biotechnol. 34:201. 19. Tomas, F.M. et al. (1993) Biochem. J. 291:781. 20. Tomas, F.M. et al. (1996) J. Endocrinol. 150:77. 21. Tomas, F.M. et al. (1997) J. Endocrinol. 155:377. 22. von der Thüsen, J.H. et al. (2011) Am. J. Pathol. 178:924
Function	Recombinant human long-acting IGF-1 variant (LR3 IGF-1) has enhanced stability and bioactivity. It is suitable for long-term cell proliferation research, muscle regeneration experiments, and exploration of mechanisms related to metabolic diseases.
Product Declaration	This product is for research use only and must not be used directly on the human body or for injection.
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -27℃. Avoid repeated freeze-thaw cycles.
Product Full Name	Recombinant Human LR3 IGF-I Protein
Target	LR3 IGF-I

FAQ

What is the difference between LR3 IGF-1 and regular IGF-1?

It is an analog of IGF-1, with stronger binding affinity to the IGF-1 receptor, and its half-life in the body is significantly prolonged.
When should it be used in culture?

When a stronger and more durable growth-promoting and anti-apoptotic signal is needed, such as during high-density stem cell expansion or when cells are under stress conditions.

PRODUCT CENTER

Recombinant Human LR3 IGF-I Protein

Product Number

Alias

Specifications

What is the difference between LR3 IGF-1 and regular IGF-1?

When should it be used in culture?

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