Recombinant Human SHH Protein, No Tag
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Product Number
KRP679
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Alias
Human SHH,HHG1, HHG-1, HLP3, HPE3, MCOPCB5
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Specifications
- 100ug
- 500ug
- 1mg
Product Description
| Alias | Human SHH,HHG1, HHG-1, HLP3, HPE3, MCOPCB5 |
| Catalog Number | KRP679 |
| Product Introduction | The N-terminal active fragment of recombinant human hedgehog factor is a core signaling protein that regulates embryonic development and tissue regeneration. Suitable for developmental biology research, neural differentiation experiments, and tissue regeneration research. |
| Molecular Name | SHH |
| Species | Human |
| Host | E.coli |
| Size | 100ug,500ug,1mg |
| Purity | >97%, determined by SDS-PAGE. |
| Concentration | Contact the sales manager to obtain the concentration of the latest batch. |
| Purification | Affinity Purification |
| Endotoxin | <0.01 EU/μg, determined by LAL method. |
| Background | The key ligand protein of the hedgehog signaling pathway, whose N-terminal domain is the part that exerts biological activity. It plays a core role in embryonic development, tissue differentiation, and stem cell maintenance, with abnormal activation associated with various cancers. |
| Application | WB, ELISA |
| Predicted Molecular Weight | 20 kDa |
| Reconstitution | It is recommended that the lyophilized human Sonic Hedgehog, N-Terminus protein be dissolved in sterile deionized water at a concentration of 250 μg/mL for further dilution as the working concentration. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -84℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Stability | Repeated freezing and thawing is not recommended. |
| Molecular Weight | 22 kDa |
| Uniprot ID | Q15465 |
| References | 1. Briscoe, J. and P.P. Therond (2013) Mol. Cell. Biol. 14:416. 2. Aviles, E.C. et al. (2013) Front. Cell. Neurosci. 7:86. 3. Xie, J. et al. (2013) OncoTargets Ther. 6:1425. 4. Marigo, V. et al. (1995) Genomics 28:44. 5. Zeng, X. et al. (2001) Nature 411:716. 6. Feng, J. et al. (2004) Development 131:4357. 7. Goetz, J.A. et al. (2006) J. Biol. Chem. 281:4087. 8. Pepinsky, R.B. et al. (1998) J. Biol. Chem. 273:14037. 9. Chen, M.-H. et al. (2004) Genes Dev. 18:641. 10. Etheridge, L.A. et al. (2010) Development 137:133. 11. Jakobs, P. et al. (2014) J. Cell Sci. 127:1726. 12. Dierker, T. et al. (2009) J. Biol. Chem. 284:8013. 13. Lewis, P.M. et al. (2001) Cell 105:599. 14. Carpenter, D. et al. (1998) Proc. Natl. Acad. Sci. USA 95:13630. 15. Filmus, J. and M. Capurro (2014) Matrix Biol. 35:248. 16. Chuang, P.-T. and A.P. McMahon (1999) Nature 397:617. |
| Function | Recombinant human sonic hedgehog N-terminal active fragment is a core signaling protein that regulates embryonic development and tissue regeneration. It is applicable for developmental biology research, neural differentiation experiments, and tissue regeneration studies. |
| Product Declaration | This product is for research use only and must not be used directly on the human body or for injection. |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -24℃. Avoid repeated freeze-thaw cycles. |
| Product Full Name | Recombinant Human Sonic Hedgehog N-Terminus, Protein |
| Target | SHH |
FAQ
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What is the SHH protein?
It is the key molecule of the Hedgehog signaling pathway, playing a core regulatory role in embryonic development, cell fate determination, and tissue pattern formation.
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What are its key applications in stem cell research?
It is a key inducer for the differentiation of neural stem cells into ventral-type neurons (such as motor neurons, dopaminergic neurons); it is also used in the culture of organoids such as intestines and lungs to establish correct tissue structures.
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