Recombinant Human IL-6 Protein

Product Number

KRP674

Alias

Interleukin-6,BSF2,HSF,IFNB2

Specifications

100ug
500ug
1mg

DATASHEET MSDS

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Product Description

Alias	Interleukin-6,BSF2,HSF,IFNB2
Catalog Number	KRP674
Product Introduction	Recombinant human IL-6 protein is a high-purity cytokine produced using the Escherichia coli expression system, and its amino acid sequence and biological activity are highly consistent with natural human interleukin-6. This product has ultra-high specific activity (ED ₅₀<1 ng/mL) and excellent purity (>95%), with extremely low endotoxin content, ensuring the reliability and reproducibility of experimental results. As a core messenger molecule in immune and inflammatory responses, it is a key tool for studying immune regulation, hematopoietic development, tumor microenvironment, and autoimmune diseases. Widely used in in vitro cell culture expansion, exploration of signaling pathway mechanisms, and drug screening and development, it is an ideal core reagent for promoting basic research in life sciences and the development of translational medicine.
Molecular Name	IL6
Species	Human
Host	E.coli
Size	100ug,500ug,1mg
Purity	>97%, determined by SDS-PAGE.
Concentration	Contact the sales manager to obtain the concentration of the latest batch.
Purification	Affinity Purification
Endotoxin	<0.1EU/μg, determined by LAL method.
Background	IL-6 is a key cytokine that plays a significant role in immune defense, acute inflammation, and hematopoiesis. Antibody drugs targeting IL-6 or its receptor have become important targeted therapies for the treatment of diseases such as rheumatoid arthritis and cytokine storms.
Application	WB, ELISA
Predicted Molecular Weight	20.9 kDa
Reconstitution	It is recommended that the lyophilized human IL-6 protein be dissolved in PBS at a concentration of 100-200 μg/ml for further dilution as the working concentration.
Storage Condition	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Stability	Repeated freezing and thawing is not recommended.
Molecular Weight	20-21 kDa
Uniprot ID	P05231
References	1. Mansell, A. and B.J. Jenkins (2013) Cytokine Growth Factor Rev. 24:249.. Schuett, H. et al. (2009) Thromb. Haemost. 102:215.. Erta, M. et al. (2012) Int. J. Biol. Sci. 8:1254.. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85.. Mihara, M. et al. (2012) Clin. Sci. (Lond.) 122:143.. Hirano, T. et al. (1986) Nature 324:73.. Kestler, D.P. et al. (1995) Blood 86:4559.. Kestler, D.P. et al. (1999) Am. J. Hematol. 61:169.. Bihl, M.P. et al. (2002) Am. J. Respir. Cell Mol. Biol. 27:48.0. Alberti, L. et al. (2005) Cancer Res. 65:2.1. Murakami, M. et al. (1993) Science 260:1808.2. Muller-Newen, G. (2003) Sci. STKE 2003:PE40.3. Mitsuyama, K. et al. (2006) Clin. Exp. Immunol. 143:125.4. Cerutti, A. et al. (1998) J. Immunol. 160:2145.
Function	A key tool for studying immunomodulation, hematopoietic development, tumor microenvironment, and autoimmune diseases, widely used in in vitro cell culture expansion, exploration of signal pathways, and drug screening and development, is the ideal core reagent for advancing basic life science research and translational medical development.
Product Declaration	This product is for research use only and must not be used directly on the human body or for injection.
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Product Full Name	Recombinant Human IL-6 Protein
Target	IL6

FAQ

How should proteins expressed in 293F cells be stored?

Proteins can be stored at -80°C for long-term preservation. They should be aliquoted and freezing and thawing cycles should be avoided to maintain protein stability.
Should special attention be paid to the dual nature of IL-6 when using it?

Yes. IL-6 has a dual role of promoting proliferation/differentiation and inflammation/aging, and it is necessary to control the concentration and duration of action based on the experimental purpose. Long-term high concentrations of IL-6 may lead to stem cell exhaustion or abnormal differentiation.

PRODUCT CENTER

Recombinant Human IL-6 Protein

Product Number

Alias

Specifications

How should proteins expressed in 293F cells be stored?

Should special attention be paid to the dual nature of IL-6 when using it?

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