KMP4953
Stress-activated protein kinase kinase 2 (SAPK kinase 2;SAPKK-2;SAPKK2), SKK2, PRKMK3, MKK3, MEK3, MAPKK 3, MAPK/ERK kinase 3 (MEK 3), MAP2K3, MAP kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 3
| Alias | Stress-activated protein kinase kinase 2 (SAPK kinase 2;SAPKK-2;SAPKK2), SKK2, PRKMK3, MKK3, MEK3, MAPKK 3, MAPK/ERK kinase 3 (MEK 3), MAP2K3, MAP kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 3 |
| Catalog Number | KMP4953 |
| Product Description | MAP2K3 protein is a bispecific protein kinase belonging to the MAP kinase kinase family. This kinase is activated by mitosis and environmental stress and participates in the MAP kinase mediated signaling cascade. It phosphorylates and activates MAPK14/p38-MAPK. This kinase can be activated by insulin and is a necessary condition for the expression of glucose transporters. The expression of Ras oncogene leads to the accumulation of the active form of this kinase, thereby promoting the essential activation of MAPK14 and endowing primary cells with carcinogenic transformation. The inhibition of this kinase is involved in the pathogenesis of Yersinia pseudomorpha. |
| Molecular Name | MAP2K3 |
| Species | Human |
| Host | E.coli |
| Size | 20ug,100ug,1mg |
| Protein Family | MAP kinase family |
| Purity | ≥95% |
| Purification | Affinity purification |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 20 mM HEPES, 150 mM NaCl, pH 7.4 |
| Background | MAP2K3 protein is a bispecific protein kinase belonging to the MAP kinase kinase family. This kinase is activated by mitosis and environmental stress and participates in the MAP kinase mediated signaling cascade. It phosphorylates and activates MAPK14/p38-MAPK. This kinase can be activated by insulin and is a necessary condition for the expression of glucose transporters. The expression of Ras oncogene leads to the accumulation of the active form of this kinase, thereby promoting the essential activation of MAPK14 and endowing primary cells with carcinogenic transformation. The inhibition of this kinase is involved in the pathogenesis of Yersinia pseudomorpha. |
| Tag | N-His，C-Avi |
| Biological Activity | Not Test |
| Predicted Molecular Weight | 48.6kDa |
| Reconstitution | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL |
| Storage Condition | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | Dry ice transportation |
| Stability | It is not recommended to repeatedly freeze and thaw |
| Sequence | 1-347AA |
| Molecular Weight | 48.6kDa |
| Uniprot ID | P46734 |
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