KMP4951
黏蛋白 16 / 癌抗原 125; Mucin-16, MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125, MUC16
| Alias | 黏蛋白 16 / 癌抗原 125; Mucin-16, MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125, MUC16 |
| Catalog Number | KMP4951 |
| Product Description | The Recombinant Human MUC16/CA125 Protein with Strep Tag (KMP4951) is expressed from mammalian cells. It contains 13360-14347 AA. |
| Molecular Name | MUC16/CA125 |
| Species | Human |
| Host | Mammalian Cells |
| Size | 50ug, 100ug |
| Purity | > 90% as determined by SDS-PAGE |
| Purification | Affinity Purification |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Background | As a member of the mucin family, MUC16 (also known as CA125) is a type I transmembrane glycoprotein characterized by a large extracellular domain with tandem repeats, a transmembrane domain, and a short cytoplasmic tail. It functions as a component of the mucosal barrier and participates in epithelial protection and immune modulation. Frequently overexpressed in ovarian carcinomas, MUC16 promotes tumor progression by facilitating cell proliferation and inhibiting immune surveillance. Its cytoplasmic tail interacts with signaling molecules such as β-catenin and Src family kinases, potentially contributing to oncogenic pathways. Alternative splicing generates multiple isoforms, though their distinct functional roles remain to be fully characterized. |
| Tag | C-Strep |
| Predicted Molecular Weight | 112.78 kDa |
| Reconstitution | Reconstitute in sterile water for a stock solution. |
| Storage Condition | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
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