Mouse CD122 Protein, hFc Tag
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Product Number
KMP3967
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Alias
白介素-2 受体 beta, CD122 Protein, Mouse CD122 Protein, hFc Tag
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 白介素-2 受体 beta, CD122 Protein, Mouse CD122 Protein, hFc Tag |
| Catalog Number | KMP3967 |
| Product Description | The Mouse CD122 Protein(KMP3967) is produced in HEK293 Cells. A DNA sequence encoding the Mouse IL2RB (NP_032394.1) (Met1-Glu240) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | CD122 |
| Species | Mouse |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Interleukin-2 receptor (IL-2R) also known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms concerning the ability to bind interleukin 2. The low-affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high-affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high-affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 51.76 kDa |
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