Cynomolgus ERBB2 Protein, His Tag, Avi Tag
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Product Number
KMP3678
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Alias
酪氨酸激酶受体2, ERBB2 Protein, Cynomolgus ERBB2 Protein, His Tag, Avi Tag
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 酪氨酸激酶受体2, ERBB2 Protein, Cynomolgus ERBB2 Protein, His Tag, Avi Tag |
| Catalog Number | KMP3678 |
| Product Description | The Cynomolgus ERBB2 Protein(KMP3678) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus ERBB2 (XP_001090430.1) (Met1-Thr652) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| Molecular Name | ERBB2 |
| Species | Cynomolgus |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 72.63 kDa |
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