Human NPC1 Protein, His Tag, Flag Tag
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Product Number
KMP3385
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Alias
细胞内胆固醇转运蛋白 1, Human NPC1 Protein, His Tag, FLAG Tag, NPC1
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 细胞内胆固醇转运蛋白 1, Human NPC1 Protein, His Tag, FLAG Tag, NPC1 |
| Catalog Number | KMP3385 |
| Product Description | The Human NPC1 Protein(KMP3385) is produced in HEK293 Cells. The target gene encoding the human NPC1 (NP_000262.2) (Arg372-Phe622) is expressed with a N-terminal polyHistide-tagged FLAG tag at the N-terminus (His-FLAG). |
| Molecular Name | NPC1 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick type C1. NPC1 localizes predominantly to late endosomes and has a dileucine motif located within a small cytoplasmic tail thought to target the protein to this location. Niemann-Pick disease type C1 (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. On the cellular level, NPC1 mutations lead to an accumulation of cholesterol and gangliosides. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 32 kDa |
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