Human FNDC4 Protein, mFc Tag
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Product Number
KMP3233
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Alias
含纤连蛋白 III 型域 4, Human FNDC4 Protein, mFc Tag, FNDC4
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 含纤连蛋白 III 型域 4, Human FNDC4 Protein, mFc Tag, FNDC4 |
| Catalog Number | KMP3233 |
| Product Description | The Human FNDC4 Protein(KMP3233) is produced in HEK293 Cells. The target gene encoding the human FNDC4 (NP_073734.1) (Met1-Thr167) is expressed with the Fc region of mouse IgG1 at the C-terminus. |
| Molecular Name | FNDC4 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >85% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. That FNDC4 may be a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 39.7 kDa |
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