Human NRBF2 Protein, His Tag, GST Tag
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Product Number
KMP3159
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Alias
核受体结合因子 2, Human NRBF2 Protein, His Tag, GST Tag, NRBF2
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 核受体结合因子 2, Human NRBF2 Protein, His Tag, GST Tag, NRBF2 |
| Catalog Number | KMP3159 |
| Product Description | The Human NRBF2 Protein(KMP3159) is produced in Insect Cells. The target gene encoding the human NRBF2 (Q96F24-1) (Met1-Asn287) is expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Molecular Name | NRBF2 |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >85% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM Tris, 500mM NaCl, 10% Glycerol, pH7.4 |
| Background | NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. NRBF2, a key component, and regulator of the PtdIns3K has been involved in APP-CTFs homeostasis in Alzheimer's disease (AD) cell models. NRBF2 plays an important role in regulating the degradation of APP-CTFs through modulating autophagy. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 60.2 kDa |
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