Human VISTA Protein, hFc Tag
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Product Number
KMP3072
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Alias
V 型免疫调节受体, Human VISTA Protein, hFc Tag, VISTA
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | V 型免疫调节受体, Human VISTA Protein, hFc Tag, VISTA |
| Catalog Number | KMP3072 |
| Product Description | The Human VISTA Protein(KMP3072) is produced in HEK293 Cells. The target gene encoding the human C10orf54 (AAH20568.1) (Met1-Ala194) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | VISTA |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. VSIR is broadly expressed in the spleen, bone marrow, and other tissues. Diseases associated with VSIR include Ichthyosis, Congenital, Autosomal Recessive 6, and Monckeberg Arteriosclerosis. An important paralog of this gene is VSIG8. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 44.9 kDa |
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