Human TIE2 Protein, His Tag
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Product Number
KMP2711
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Alias
内皮细胞TEK酪氨酸激酶, Human TIE2 Protein, His Tag, TIE2
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 内皮细胞TEK酪氨酸激酶, Human TIE2 Protein, His Tag, TIE2 |
| Catalog Number | KMP2711 |
| Product Description | The Human TIE2 Protein(KMP2711) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Lys745) of human Tie2 (AAA61139.1) precursor is fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro. |
| Molecular Name | TIE2 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 82 kDa |
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