Human B7-1 Protein, hFc Tag
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Product Number
KMP2706
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Alias
抗原分化簇80, Human B7-1 Protein, hFc Tag, B7-1
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 抗原分化簇80, Human B7-1 Protein, hFc Tag, B7-1 |
| Catalog Number | KMP2706 |
| Product Description | The Human B7-1 Protein(KMP2706) is produced in HEK293 Cells. The target gene encoding the human CD80 (NP_005182.1) (Met1-Asn242) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | B7-1 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 50.6 kDa |
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