Human c-MET Protein, hFc Tag
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Product Number
KMP2696
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Alias
间质表皮转化因子, Human c-MET Protein, hFc Tag, c-MET
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 间质表皮转化因子, Human c-MET Protein, hFc Tag, c-MET |
| Catalog Number | KMP2696 |
| Product Description | The Human c-MET Protein(KMP2696) is produced in HEK293 Cells. The target gene encoding the human MET (NP_000236) (Met1-Thr932) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | c-MET |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 128.4 kDa |
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