Human ALK4 Protein, hFc Tag
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Product Number
KMP2657
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Alias
激活素受体 1B 型, Human ALK4 Protein, hFc Tag, ALK4
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 激活素受体 1B 型, Human ALK4 Protein, hFc Tag, ALK4 |
| Catalog Number | KMP2657 |
| Product Description | The Human ALK4 Protein(KMP2657) is produced in HEK293 Cells. The target gene encoding the human ACVR1B (NP_004293.1) (Met1-Glu126) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | ALK4 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 38.1 kDa |
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