Human NKG2D Protein, mFc Tag
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Product Number
KMP2654
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Alias
杀伤细胞凝集素样受体 K 亚家族成员 1, Human NKG2D Protein, mFc Tag, NKG2D
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 杀伤细胞凝集素样受体 K 亚家族成员 1, Human NKG2D Protein, mFc Tag, NKG2D |
| Catalog Number | KMP2654 |
| Product Description | The Human NKG2D Protein(KMP2654) is produced in Insect Cells. The target gene encoding the Human KLRK1 (P26718-1) (Phe78-Val216) is expressed with the Fc region of mouse IgG1 at the N-terminus. |
| Molecular Name | NKG2D |
| Species | Human |
| Host | Insect Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM Tris, 300mM NaCl, 10% Glycerol, pH7.5 |
| Background | KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. To transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 41.83 kDa |
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