Human CD162 Protein, mFc Tag
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Product Number
KMP2634
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Alias
选择素 P 配体, Human CD162 Protein, mFc Tag, CD162
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 选择素 P 配体, Human CD162 Protein, mFc Tag, CD162 |
| Catalog Number | KMP2634 |
| Product Description | The Human CD162 Protein(KMP2634) is produced in HEK293 Cells. The target gene encoding the human SELPLG (AAC50061.1) (Met1-Val295) is expressed with the Fc region of mouse IgG1 at the C-terminus. |
| Molecular Name | CD162 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein, expressed on leukocytes and platelets as a homodimer of two disulfide-linked subunits of ~12 kD. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 protein requires two distinct posttranslational modifications for the Ca2+-dependent recognition by the lectin domain of P-selectin, that is tyrosine sulfation and specific O-linked glycosylation (sialic acid and fucose). PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 55.4 kDa |
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