Human C-MPL Protein, His Tag
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Product Number
KMP2607
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Alias
血小板生成素受体, Human C-MPL Protein, His Tag, C-MPL
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 血小板生成素受体, Human C-MPL Protein, His Tag, C-MPL |
| Catalog Number | KMP2607 |
| Product Description | The Human C-MPL Protein(KMP2607) is produced in HEK293 Cells. The target gene encoding the Human MPL (P40238-1) (Met1-Trp491) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | C-MPL |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. The presence of anti-sense oligodeoxynucleotides of C-Mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for C-Mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopenia which is a disease characterized by isolated thrombocytopenia and Megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 54 kDa |
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