Human IL-6R Protein, hFc Tag
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Product Number
KMP2590
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Alias
白介素-6 受体, Human IL-6R Protein, hFc Tag, IL-6R
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 白介素-6 受体, Human IL-6R Protein, hFc Tag, IL-6R |
| Catalog Number | KMP2590 |
| Product Description | The Human IL-6R Protein(KMP2590) is produced in HEK293 Cells. The target gene encoding the human IL6R (NP_000556.1) (Met1-Pro365) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | IL-6R |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 65.3 kDa |
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