Human IL13RA2 Protein, His Tag
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Product Number
KMP2569
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Alias
白细胞介素 13 受体亚基 α 2, Human IL13RA2 Protein, His Tag, IL13RA2
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 白细胞介素 13 受体亚基 α 2, Human IL13RA2 Protein, His Tag, IL13RA2 |
| Catalog Number | KMP2569 |
| Product Description | The Human IL13RA2 Protein(KMP2569) is produced in HEK293 Cells. The target gene encoding the extracellular domain of human IL13Rα2 (NP_000631.1) (Met1-Leu342) is expressed with the a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro. |
| Molecular Name | IL13RA2 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >85% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High-Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Rα2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Rα2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Rα2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 38 kDa |
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