Human HAVCR2 Protein, Fc Tag, His Tag
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Product Number
KMP2382
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Alias
甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2 |
| Catalog Number | KMP2382 |
| Product Description | The Human HAVCR2 Protein(KMP2382) is produced in HEK293 Cells and the target gene encoding Ser22-Arg200 is expressed with a Fc, 6His tag at the C-terminus. |
| Molecular Name | HAVCR2 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >90% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Hepatitis A virus cellular receptor 2(HAVCR2)is a single-pass type I membrane protein and it contains 1 Ig-like V-type(immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte(Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4(MIM 186940)-positive T helper lymphocytes can be divided into types 1(Th1) and 2(Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. |
| SDS-PAGE | |
| Predicted Molecular Weight | 20.7 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | E5RFR4 |
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