Mouse CD137 Protein, Fc Tag
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Product Number
KMP2373
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Alias
肿瘤坏死因子超家族受体9, CD137, ILA
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 肿瘤坏死因子超家族受体9, CD137, ILA |
| Catalog Number | KMP2373 |
| Product Description | The Mouse CD137 Protein(KMP2373) is produced in HEK293 Cells and the target gene encoding Val24-Leu187 is expressed with a Fc tag at the C-terminus. |
| Molecular Name | CD137 |
| Species | Mouse |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM PB, 150mM NaCl, pH7.4 |
| Background | Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor(TNF) receptor family. It can be induced by lymphocyte activation(ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. |
| Predicted Molecular Weight | 17.4 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | P20334 |
| Function | Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8+ T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (By similarity). |
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