Rabbit CD80 Protein, His Tag
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Product Number
KMP2331
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Alias
T淋巴细胞活化抗原CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | T淋巴细胞活化抗原CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen |
| Catalog Number | KMP2331 |
| Product Description | The Rabbit CD80 Protein(KMP2331) is produced in HEK293 Cells and the target gene encoding Gly33-Gln241 is expressed with a 6His tag at the C-terminus. |
| Molecular Name | CD80 |
| Species | Rabbit |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. |
| SDS-PAGE | |
| Predicted Molecular Weight | 24.47 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | P42070 |
| Function | Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. |
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