Recombinant Human CD33 Protein, His Tag

Name: Recombinant Human CD33 Protein, His Tag
Brand: KMD Bioscience
SKU: KMH188

KMH188

p67, SIGLEC3, SIGLEC 3, CD33 molecule

DATASHEET MSDS

Product Description

Alias	p67, SIGLEC3, SIGLEC 3, CD33 molecule
Catalog Number	KMH188
Molecular Name	CD33
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	CD molecule
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	Myeloid cell surface antigen CD33 also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33/Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, one Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. CD33/Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33/Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	28.71 kDa
Note	仅供科研使用

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