Recombinant Human TIMP-2 Protein, His Tag

Name: Recombinant Human TIMP-2 Protein, His Tag
Brand: KMD Bioscience
SKU: KMH1810

KMH1810

DDC8, CSC 21K, TIMP metallopeptidase inhibitor 2

DATASHEET MSDS

Product Description

Alias	DDC8, CSC 21K, TIMP metallopeptidase inhibitor 2
Catalog Number	KMH1810
Molecular Name	TIMP2
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	The tissue Inhibitor of Metalloproteinases (TIMP) belongs to a family which takes part in the activation and regulation of the MMP-activity: TIMP-1, a 28-kDa glycoprotein, TIMP-2, a 21-kDa glycoprotein and the N-glycosylated TIMP-3 (27-kDa, reduced SDS-PAGE). TIMP-4 is thought to function in a tissue-specific fashion in the ECM hemostasis. These proteins are expressed in a variety of cell types and form with latent as well as with active MMPs non-covalent, stoichiometric complexes. Progelatinase B and the activated gelatinase B specifically bind TIMP-1 via their C-terminal domain. Purified TIMP-2 inhibits the activities of stromelysin 1 (MMP-3), matrilysin (MMP-7), gelatinase A (MMP-2) and the interstitial collagenase (MMP-1).On the MMP-2 the TIMP displays two distinct binding sites.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	21.34 kDa
Note	仅供科研使用

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