Human CD8 alpha Protein, hFc Tag
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Product Number
KMP2813
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Alias
分化群8, Human CD8 alpha Protein, hFc Tag, CD8 alpha
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Specifications
- 50ug
- 100ug
- 200ug
Product Description
| Alias | 分化群8, Human CD8 alpha Protein, hFc Tag, CD8 alpha |
| Catalog Number | KMP2813 |
| Product Description | The Human CD8 alpha Protein(KMP2813) is produced in HEK293 Cells. The target gene encoding the human CD8A (NP_001759.3) (Met1-Asp182) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | CD8 alpha |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 44.3 kDa |
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